Oral Adherence

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Venclexta

  • 1.  Venclexta

    Posted 11 days ago
    For those who've had patients on Venclexta (venetoclax tablets) - What are the challenges you've faced with patient initiation and SE management?

    Thank you for your input!
    Shari Bates


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    Shari Bates, BSN, RN, OCN
    Auburn WA
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  • 2.  RE: Venclexta

    Posted 10 days ago
    ​Hi Shari,

    We have started multiple patients on venetoclax for its various indications and have found it generally well tolerated with many of our patients reaching full dose after the scheduled ramp ups.

    Key considerations include:

    • Dosing appropriate for diagnosis (CLL vs AML)
    • Determining TLS risk and planning appropriate prophylaxis – hospitalization(rare) vs. IV fluids in clinic vs. pushing oral intake, and allopurinol
    • Laboratory monitoring 6-8 hours after first dose, at 24 hours, and with each weekly ramp up
    • Timing start date when given with obinutuzumab (day 22 ) 
    Biggest challenge: Treating patients with venetoclax requires close communication and collaboration with the provider, nursing team, pharmacy and patient.
    • Have designated personnel to oversee acquisition and scheduling appointments on start date
    • Instruct the patient do not start the medication without communicating with the team in advance,
    • Track patients at least weekly in person for adherence and toxicity checks with the weekly labs and ramp up.
    The manufacturer has wonderful patient education materials including a color-coded calendar that corresponds to each weekly blister pack. So be sure to reach out to your rep if you have not already done so!

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    Mary K Anderson BSN RN OCN
    Oral Oncolytic Nurse Navigator
    Norton Cancer Institute
    Louisville KY
    mary.anderson@nortonhealthcare.org
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  • 3.  RE: Venclexta

    Posted 9 days ago
    Thank you for your Venclexta responses, they are all so helpful!

    This community is a wonderful resource!

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    Shari Bates BSN RN OCN CCM
    Auburn WA
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