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Thiotepa-PPE for general care

  • 1.  Thiotepa-PPE for general care

    Posted 08-13-2019 11:30

    Good Day to You:


    We have just compiled skin care guidelines for using Thiotepa. My question for the group is what gloves you are using for general patient care such as linen changes, clothing, and patient contact. Are you using standard gloves for this or do you continue to use the gloves specifically tested to protect against Thiotepa breakthrough.  The only reference I have found thus far is to use standard precautions. 

    Your thoughts

    Thank you




    Margaret M. Bellerjeau MSN, RN,OCN, CHTC, BMTCN

    Program Development Educator

    Fox Chase- Temple Bone Marrow Transplant Program

    Phone: 215-214-3123

    Fax:     215-214-3127




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  • 2.  RE: Thiotepa-PPE for general care

    Posted 08-14-2019 10:57

    Our normal exam gloves, FitGuard Select Gloves, were not rated for use with Carmustine and Thiotepa. Most gloves will have this information on the back of the box or on the manufacturer website. We found SafeSkin Purple Nitrile-Xtra Powder-Free Exam Gloves were rated for use with Carmustine and Thiotepa (See below information from the manufacturer.) Hope this helps!



    HALYARD* PURPLE NITRILE* Powder-Free Exam Gloves have been tested according to the tests listed above. C15istered Trademark or Trademark of Halyard Health, Inc. or its affiliates. The COLOR PURPLE is a Registered Trademark of Halyard Health, Inc. or its affiliates.

    © 2015 HYH. All rights reserved.

    e following chemotherapy drugs and had NO breakthrough detected up to 240 minutes:

    Bleomycin sulfate (15 mg/ml)

    Busulfan (6 mg/ml)

    Carboplatin (10 mg/ml)

    Cisplatin (1.0 mg/ml)

    Cyclophosphamide (20.0 mg/ml)

    Cytarabine HCl (100 mg/ml)

    Dacarbazine (10 mg/ml)

    Daunorubicin HCl (5.0 mg/ml)

    Docetaxel (10.0 mg/ml)

    Doxorubicin HCl (2.0 mg/ml)

    Epirubicin (Ellence) (2 mg/ml)

    Etoposide (20.0 mg/ml)

    Fludarabine (25 mg/ml)

    Fluorouracil (50.0 mg/ml)

    Gemcitabine HCl (38.0mg/ml)

    Idarubicin HCl (1.0mg/ml)

    Ifosfamide (50.0 mg/ml)

    Irinotecan HCl (20.0 mg/ml)

    Mechlorethamine HCl (1.0 mg/ml)

    Melphalan (5 mg/ml)

    Methotrexate (25 mg/ml)

    Mitomycin-C (0.5 mg/ml)

    Mitoxantrone (2.0 mg/ml)

    Paclitaxel (6.0 mg/ml)

    Rituximab (10 mg/ml)

    Trisenox (0.1 mg/ml)

    Vincristine Sulfate (1.0 mg/ml)

    PURPLE NITRILE-XTRA* sterile exam gloves also provide protection against the following drugs.

    Breakthrough times listed:

    ThioTEPA (10.0 mg/ml)

    Carmustine (3.3 mg/ml)

    No breakthrough to 240 minutes

    Breakthrough detected in 48 minutes

    Chemotherapy Permeation Testing per ASTM D6978-05 "Standard Practice for Assessment of Resistance

    of Medical Gloves to Permeation by Chemotherapy Drugs"

    The following chemicals had NO breakthrough detected up to 240 minutes:

    Ethidium Bromide, 0.4%

    Sodium Hydroxide, 40%

    Sulfuric Acid, 50%

    Formalin, 10%

    Glutaraldehyde, 4%

    Povidone Iodine, 10%

    Chlorhexidine Gluconate, 4%

    Sodium Hypochlorite, 10-13%

    Quaternary Disinfectant Cleaner

    PURPLE NITRILE-XTRA* sterile exam gloves provide additional protection against the following chemicals.

    Breakthrough times listed:

    Hydrogen Peroxide, 30% 20 minutes

    n-Hexane, 96.1% 19 minutes

    Isopropyl Alcohol, 70% 52 minutes

    Ortho-phthalaldehyde/Cidex OPA 93 minutes

    HCL, 37% 230 minutes

    ASTM F739 Standard Test Method for Permeation of Liquids and Gases through Protective Clothing materials

    under Conditions of Continuous Contact




    Michelle Payne MSN, RN, OCN, BMTCN
    Nurse Educator

    Wake Forest Baptist Health

    7CC West BMT and 7CC East Hem/Onc
    Medical Center Boulevard  \  Winston-Salem, NC 27157
    p 336.713.7694 \  f 336.716.5399/ pager 6815  \