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SQ Herceptin (Herceptin Hylecta) post-injection observation time

  • 1.  SQ Herceptin (Herceptin Hylecta) post-injection observation time

    Posted 08-16-2019 11:42
    For those already giving SQ Trastuzumab, are you observing patients for a period of time post-first dose?  The product information isn't specific but says "Closely monitor patients for systemic hypersensitivity reactions, especially during the first administration of Herceptin HYLECTA"
    Thanks! Susan

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    Susan Yackzan PhD APRN MSN AOCN
    Research Consultant/Oncology CNS
    Baptist Health Lexington
    LEXINGTON KY
    syackzan@bhsi.com
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  • 2.  RE: SQ Herceptin (Herceptin Hylecta) post-injection observation time

    Posted 08-18-2019 21:16
    For the 1st cycle , drug company recomment to observe about 6 hours( a SafeHer clinical trial)! For subsequence cycle,it recomment to observe for 2 hours.  By the liturature, hypersensitivity probably in 2 hours after administration, In my practice, I do observe for 2 hour for the 1st cycle and for the subsequence cycle, I do abserve an hour or less. Also, Trastuzumab is a pure humanized MAb, so it is less this reaction!  Doubful, Who doprepare Trastuzumab? Pharmacist by using BSC class II carbinet? Or nurse prepare at the OPD clinic, using anyprotection? transfer device?
    Thanks/Suwannee (APN in Oncology nursing Thailand)

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    Suwannee Sirilerttrakul RN APN
    Bangkok
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  • 3.  RE: SQ Herceptin (Herceptin Hylecta) post-injection observation time

    Posted 30 days ago
    we take a set of vital signs upon completion and then observe the pt for a minimum of 15 minutes

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    Nancy Ehmke RN MN AOCN
    CLINICAL NURSE SPECIALIST
    [Fort WayneCity] IN
    Laotto
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