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Cisplatin Administration

  • 1.  Cisplatin Administration

    Posted 09-11-2019 08:54
    Hey All!

    I have recently transitioned to a new position in a community medical oncology practice; I was presented with the question of how quickly cisplatin is administered in other clinics I have been in.  Unfortunately because I was in radiation prior to this, i am not familiar with other practices.  I am hoping to gain some insight into other peoples practices.

    Per discussion with nursing staff, they advised that the maximum speed they administer cisplatin is 1 mg/min.

    Additionally, does anyone have any specific protocols on hydration/electrolyte replacement for cisplatin and head and neck cancer patients?

    Appreciate any insight!

    Thank you!


    Elizabeth Rauschenberg MSN APRN FNP-C FNP-C
    Nurse Practitioner
    Crofton MD

  • 2.  RE: Cisplatin Administration

    Posted 09-12-2019 10:06

    Per most of our protocols, cisplatin is run over 1 hour and since protocols are based off of how drug was given in trial, that is how infusion rates are usually defined.  This is from Lexicomp:   Cisplatin has been infused (off-label rates) over 30 minutes to 4 hours, at a rate of 1 mg/minute, or as a continuous infusion (off-label rates); infusion rate varies by protocol (refer to specific protocol for infusion details). Do not administer as a rapid IV injection. 

    Also, per NCCN:


    Joy Lombardi, BSN, RN, OCN

    Nursing Director

    Huntsman Outpatient Infusion

    Huntsman Cancer Institute





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