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Carboplatin

  • 1.  Carboplatin

    Posted 08-17-2019 06:11
    Hello everyone! If you had CARBOPLATIN reactions during infusion and what activities you take?


  • 2.  RE: Carboplatin

    Posted 08-21-2019 07:13
    Hi Ana,
    We have had carboplatin reactions at our cancer center.  It usually occurs after the patient has had several cycles of the drug.  Patients will initially c/o itchy palms, stuffy nose, or begin with a mild cough from a tickle in the throat.  It will then progress quickly to flushing & shortness of breath.  The patient is usually hypertensive & tachycardic at that point.  Once the patient begins with the initial mild symptoms, we immediately stop the infusion & administer rescue medications such as solumedrol, benadryl, pepcid, & IV fluid.  Sometimes we need to administer oxygen & mini nebs as well.  At times, the patient gets worse before they get better even with rescue meds & we administer Epi pen & call a rapid response.  Patients are usually not re-challenged after a carboplatin reaction but we have done it with success by running the infusion much slower.  To re-challenge patients require more pre-medications including a dexamethasone oral prep before arriving to the infusion suite.
    thank you,
    Tina

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    Christina Klein MSN, RN, OCN, CRNI
    Oncology Educator
    Cancer Treatment Centers of America
    Philadelphia PA
    215-537-5586
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  • 3.  RE: Carboplatin

    Posted 08-22-2019 20:25
    We have had Carboplatin reactions at our cancer center & find that reactions occur at or after 6 doses of Carbo. If it is a mild reaction, we give emergency meds such as Benadryl, Dex, Pepcid, O2 PRN, & re-challenge when symptoms resolve & pt gets back to baseline. If it is severe, we do not re-challenge. There is a GYN oncologist who orders Carboplatin desensitization for her t's who have had moderate reactions. This process can take up to 12 hours & Carbo doses start very small & titrate up in dose  every 90 minutes. There are usually a 2nd set of pre meds given after 2nd or 3rd Carbo dose (usually 4 Carbo doses are given in this regimen).

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    Marilyn Ramsey RN BSN OCN
    New Bern NC
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